Papers And Originals

Prostaglandins and Glaucoma

Br Med J 1971; 3 doi: (Published 11 September 1971) Cite this as: Br Med J 1971;3:615
  1. Anne M. Wyllie,
  2. John H. Wyllie


    Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostaglandin E1. These results suggest that prostaglandin E1 may play some part in the aetiology of open angle glaucoma.