Papers And Originals

Treatment of Duodenal Ulcer with Glycyrrhizinic-acid-reduced Liquorice: A MULTICENTRE TRIAL

Br Med J 1971; 3 doi: (Published 28 August 1971) Cite this as: Br Med J 1971;3:501

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A double-blind controlled therapeutic trial of glycyrrhizinic-acid-reduced liquorice 760 mg thrice daily for six weeks was carried out on 90 men with relapse of chronic duodenal ulcer. Effects of treatment were judged by the frequency and severity of pain, the amount of alkali consumed, and the doctors' and patients' rating of the clinical response. The results do not show any advantage for the active treatment when compared with the placebo.


  • * The following took part in the trial: Dr. J. J. Misiewicz (convener) and Dr. R. I. Russell, M.R.C. Gastroenterology Unit and Department of Gastroenterology, Central Middlesex Hospital; Dr. J. H. Baron and Mr. A. G. Cox, Prince of Wales's Hospital (J.H.B.) and Hammersmith Hospital and Royal Postgraduate Medical School (J.H.B. and A.G.C.); Dr. M. J. Grayson, Plymouth General Hospitals; Dr. J. Howel Jones, Hospital of St. Cross, Rugby; Dr. J. E. Lennard-Jones, Dr. D. G. Colin-Jones, and Dr. J. Temperley, University College Hospital; and Dr. P. Richardson, the London Hospital.