Papers And Originals

Anaesthetic-induced Malignant Hyperpyrexia: A Suggested Method of Treatment

Br Med J 1971; 3 doi: (Published 21 August 1971) Cite this as: Br Med J 1971;3:454
  1. Gaisford G. Harrison


    Experiments in susceptible Landrace pigs have shown that procaine blocks the initiation of anaesthetic-induced malignant hyperpyrexia by both halothane and succinylcholine. Pretreatment with curare prevents only the trigger action of succinylcholine. In a preliminary study procaine was used to treat the established syndrome in five pigs, two of which survived. On the basis of these findings a treatment regimen can be suggested for patients who develop malignant hyperpyrexia.