Thromboembolic Complications in MyelomatosisBr Med J 1970; 3 doi: https://doi.org/10.1136/bmj.3.5720.438 (Published 22 August 1970) Cite this as: Br Med J 1970;3:438
- D. Catovsky,
- N. B. Ikoku,
- W. R. Pitney,
- D. A. G. Galton
Fourteen cases of myelomatosis associated with major thromboembolic complications are reported. Six patients died of pulmonary embolism, seven had deep-vein thrombosis as a presenting symptom, and three had evidence of amyloidosis. A preliminary estimate of the incidence of thromboembolism based on 376 patients admitted so far to the Medical Research Council's myelomatosis trial is about 3%, while pulmonary embolism accounted for about 3% of all deaths. Possibly a hypercoagulable state and the presence of amyloidosis may be important in the pathogenesis of this complication.