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Thromboembolic Complications in Myelomatosis

Br Med J 1970; 3 doi: (Published 22 August 1970) Cite this as: Br Med J 1970;3:438
  1. D. Catovsky,
  2. N. B. Ikoku,
  3. W. R. Pitney,
  4. D. A. G. Galton


    Fourteen cases of myelomatosis associated with major thromboembolic complications are reported. Six patients died of pulmonary embolism, seven had deep-vein thrombosis as a presenting symptom, and three had evidence of amyloidosis. A preliminary estimate of the incidence of thromboembolism based on 376 patients admitted so far to the Medical Research Council's myelomatosis trial is about 3%, while pulmonary embolism accounted for about 3% of all deaths. Possibly a hypercoagulable state and the presence of amyloidosis may be important in the pathogenesis of this complication.