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Preliminary Communications

Inhibition by Aspirin of Release of Antiheparin Activity from Human Platelets

Br Med J 1969; 3 doi: (Published 16 August 1969) Cite this as: Br Med J 1969;3:394

This article has a correction. Please see:

  1. A. H. Youssef,
  2. P. Barkhan


    Both in vitro and in vivo, aspirin inhibited the adenosine diphosphate and collagen-induced release of platelet factor 4 (antiheparin factor). The release induced by adrenaline and thrombin was not affected. The in-vivo effect in normal persons lasted for at least three days. Platelet uptake of acetyl-14C-aspirin was significantly greater than that of carboxyl-14C-aspirin.

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