Papers And Originals

Circadian Rhythm of Plasma 11-Hydroxycorticosteroids in Psychiatric Disorders

Br Med J 1968; 3 doi: (Published 17 August 1968) Cite this as: Br Med J 1968;3:405
  1. R. T. W. L. Conroy,
  2. B. D. Hughes,
  3. J. N. Mills


    Studies of the circadian rhythm in plasma 11-O.H.C.S. levels showed that a subgroup of affective psychotics had higher plasma 11-OHCS values as compared with schizophrenic and other psychotic subgroups, and a somewhat less regular rhythm. One patient with depression who was studied over 48-hour periods showed a reduction in plasma 11-OHCS levels with clinical recovery. An accentuated fall and rise in plasma 11-OHCS values in the night and early morning samples, respectively, was observed in the schizophrenic subgroup.