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Preliminary Communications

Bone Marrow Colony-stimulating Activity of Sera in Infectious Mononucleosis

Br Med J 1968; 3 doi: (Published 13 July 1968) Cite this as: Br Med J 1968;3:99
  1. D. Metcalf,
  2. Britta Wahren


    From 44 to 100% of sera from patients with infectious mononucleosis exhibited the capacity to stimulate colony formation in vitro by mouse bone marrow cells. The proportion of sera with colony-stimulating activity was highest in patients with a short fever period and developing low Paul-Bunnell titres. Patients with a more severe course of the disease generally displayed no, or only weak, colony-stimulating activity in their sera, and also had higher Paul-Bunnell titres. The level of serum colony-stimulating activity tended to fall in the convalescent stages of the disease.

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