Multiple microemboli after disintegration of clot during thrombolysis for acute myocardial infarction.BMJ 1989; 299 doi: https://doi.org/10.1136/bmj.299.6711.1310 (Published 25 November 1989) Cite this as: BMJ 1989;299:1310
- P. J. Stafford,
- C. J. Strachan,
- R. Vincent,
- D. A. Chamberlain
Seven of 475 consecutive patients treated with thrombolysis for acute myocardial infarction had severe embolic complications that were believed to be caused by disintegration of pre-existing clot. Three patients had symptoms that persisted for many weeks, and five died. Any potential site of pre-existing blood clot within the vascular system, notably an enlarged left atrium, ventricular aneurysm, or aortic aneurysms, should be regarded as a contraindication to treatment with thrombolytic agents.