Intended for healthcare professionals

Research Article

Poor sulphoxidation ability in patients with food sensitivity.

British Medical Journal 1988; 297 doi: (Published 09 July 1988) Cite this as: British Medical Journal 1988;297:105
  1. G. K. Scadding,
  2. R. Ayesh,
  3. J. Brostoff,
  4. S. C. Mitchell,
  5. R. H. Waring,
  6. R. L. Smith
  1. Department of Immunology, Middlesex Hospital Medical School, London.


    Patients with well defined reactions to foods were examined for their ability to carry out both sulphur and carbon oxidation reactions by using carbocisteine and debrisoquine as probe compounds. The proportion of poor sulphoxidisers (58 of 74) was significantly greater than that of a previously determined normal control population (67 of 200; p less than 0.005). The proportion of poor carbon oxidisers was not significantly different from the controls. Metabolic defects may play a part in the pathogenesis of adverse reactions to foods.