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Clinical Research

Carcinoma in situ of the testis: aneuploid cells in semen

Br Med J (Clin Res Ed) 1988; 296 doi: (Published 25 June 1988) Cite this as: Br Med J (Clin Res Ed) 1988;296:1762
  1. Aleksander Giwercman,
  2. Ole Petter F Clausen,
  3. Niels E Skakkebæk


    The content of cellular DNA in ejaculates from eight patients with carcinoma in situ of the testis and 26 controls without evidence of testicular neoplasia was studied by flow cytometry. An aneuploid cell population with a ploidy value similar to that found for carcinoma in situ cells was detected in seminal fluid from four of the eight men with carcinoma in situ but in none of the controls. One year after orchidectomy or local irradiation in these four men no aneuploid cells were found in the semen.

    These findings show that a detectable proportion of malignant germ cells may be released into the seminal fluid of patients with carcinoma in situ of the testis. Analysis of seminal fluid may therefore aid in screening for early neoplasia of the testis.

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