Intended for healthcare professionals

Research Article

Atopic manifestations in the acquired immune deficiency syndrome: response to recombinant interferon gamma.

Br Med J (Clin Res Ed) 1987; 294 doi: (Published 09 May 1987) Cite this as: Br Med J (Clin Res Ed) 1987;294:1185
  1. J M Parkin,
  2. L J Eales,
  3. A R Galazka,
  4. A J Pinching


    Six patients with the acquired immune deficiency syndrome (AIDS) had exacerbations or recurrences of previously quiescent atopic disease when they developed immunodeficiency. Four developed a different atopic illness from that suffered previously. Atopic symptoms developed within three months after the patients developed AIDS or during prodromal illness. Two of the patients were treated with recombinant interferon gamma: both showed a striking improvement in symptoms and cellular immunity. These results indicate that cellular immunity, through interferon gamma, may have a role in regulating atopic disease.