Intended for healthcare professionals

Research Article

Impaired cell mediated immunity in haemophilia in the absence of infection with human immunodeficiency virus.

Br Med J (Clin Res Ed) 1986; 293 doi: (Published 18 October 1986) Cite this as: Br Med J (Clin Res Ed) 1986;293:978
  1. R Madhok,
  2. A Gracie,
  3. G D Lowe,
  4. A Burnett,
  5. K Froebel,
  6. E Follett,
  7. C D Forbes


    The cell mediated immune response was evaluated in vivo in 29 patients with clinically severe haemophilia by means of the dinitrochlorobenzene skin test. All patients had a response below the median normal value, and in 19 the response was on or below the lower limit of the normal range. There was no difference in skin response between patients positive and negative for the human immunodeficiency virus (HIV; formerly known as human T cell lymphotropic virus III or lymphadenopathy associated virus). In the whole group, and in seronegative patients (n = 17), there was an inverse relation between exposure to clotting factor and skin response. In seropositive patients (n = 12) no such association was apparent. This study shows that clotting factor concentrate impairs the cell mediated immune response to a new antigen in the absence of infection with HIV.