Intended for healthcare professionals

Research Article

Synthesis of histamine by Haemophilus influenzae.

Br Med J (Clin Res Ed) 1986; 292 doi: (Published 29 March 1986) Cite this as: Br Med J (Clin Res Ed) 1986;292:857

This article has a correction. Please see:

  1. B D Sheinman,
  2. J L Devalia,
  3. R J Davies,
  4. S J Crook,
  5. S Tabaqchali


    Recent findings suggest that bacteria might contribute to histamine concentrations in the sputum of patients with infective lung disease. Ten isolates of Haemophilus influenzae from patients with acute exacerbation of chronic bronchitis and emphysema, together with two reference strains, were incubated at 37 degrees C for 72 hours. Serial estimations of histamine concentrations by high pressure liquid chromatography showed significant increases at 24 and 48 hours; no increases were evident in the control samples. These findings suggest that H influenzae might contribute to inflammation and limited airflow in infective lung disease by producing histamine.