Research Article

Sulpiride and the potentiation of progestogen only contraception.

Br Med J (Clin Res Ed) 1985; 291 doi: (Published 31 August 1985) Cite this as: Br Med J (Clin Res Ed) 1985;291:559
  1. M R Payne,
  2. P W Howie,
  3. A S McNeilly,
  4. W Cooper,
  5. M Marnie,
  6. L Kidd


    A progestogen (norethisterone) and a dopamine antagonist (sulpiride) were given alone and in combination to volunteers to examine their effects on excretion of ovarian steroids. Compared with non-treatment cycles (n = 15), contraception with a progestogen alone (n = 10) was associated with increased excretion of oestrone and partial suppression of excretion of pregnanediol, suggesting partial luteinization of unruptured follicles. By contrast, the combination of norethisterone and sulpiride (n = 9) suppressed both ovarian steroids to basal values, the suppression being even greater than with sulpiride alone (n = 5). These results suggest that a combination of a progestogen with a dopamine antagonist might have a role in contraception.