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Research Article

Double blind comparative study of omeprazole 10 mg and 30 mg daily for healing duodenal ulcers.

Br Med J (Clin Res Ed) 1985; 290 doi: (Published 23 February 1985) Cite this as: Br Med J (Clin Res Ed) 1985;290:601
  1. P J Prichard,
  2. D Rubinstein,
  3. D B Jones,
  4. F J Dudley,
  5. R A Smallwood,
  6. W J Louis,
  7. N D Yeomans


    Healing of duodenal ulcers was assessed in 66 patients who received omeprazole either 10 mg or 30 mg daily for four weeks in a double blind study. Healing was rapid in both groups. At two weeks the ulcers in 15 of the 30 patients taking 10 mg daily had healed compared with 28 of the 36 (78%) taking 30 mg daily (p less than 0.03). At four weeks the respective proportions had risen to 83% (25/30) and 94% (33/35) (p greater than 0.05). In non-smokers the proportion of ulcers healed did not differ significantly with the two doses, although there was a trend for less healing at two weeks with 10 mg daily; in smokers significantly fewer ulcers (p less than 0.05) were healed with 10 mg than 30 mg daily at two weeks (7/16 (44%) v 17/21 (81%] and at four weeks (12/16 (75%) v all 21 (100%]. Adverse reactions were few and transient and were considered unlikely to be due to omeprazole.