Research Article

Measurement of autoantibodies against human eye muscle plasma membranes in Graves' ophthalmopathy.

Br Med J (Clin Res Ed) 1985; 290 doi: (Published 19 January 1985) Cite this as: Br Med J (Clin Res Ed) 1985;290:191
  1. M Faryna,
  2. J Nauman,
  3. A Gardas


    Antibodies that reacted with plasma membranes of human eye muscle but showed no binding to plasma membranes of human skeletal muscle were identified in serum of patients with Graves' ophthalmopathy. Rabbit antithyroglobulin serum at a dilution of 1 X 10(-3) to 20 X 10(-3) had no effect on the binding of these antibodies to eye muscle membrane antigens. There was no correlation between antihuman eye muscle plasma membrane antibodies and antihuman thyroid membrane antibodies or antibodies against thyroglobulin. It is suggested that specific antibodies against eye muscle membranes are present in Graves' ophthalmopathy and that this disease might represent a distinct autoimmune disorder.