Intended for healthcare professionals

Research Article

Natural progesterone and antihypertensive action.

Br Med J (Clin Res Ed) 1985; 290 doi: (Published 05 January 1985) Cite this as: Br Med J (Clin Res Ed) 1985;290:13
  1. P B Rylance,
  2. M Brincat,
  3. K Lafferty,
  4. J C De Trafford,
  5. S Brincat,
  6. V Parsons,
  7. J W Studd


    In a placebo controlled, double blind crossover study natural progesterone was given by mouth, in increasing doses, to six men and four postmenopausal women with mild to moderate hypertension who were not receiving any other antihypertensive drugs. When compared with values recorded before treatment and during administration of placebo progesterone caused a significant reduction in blood pressure, suggesting that progesterone has an antihypertensive action rather than a hypertensive one as has been previously thought. This possible protective effect of progesterone should be investigated further.