Research Article

Primary biliary cirrhosis, dark adaptometry, electro-oculography, and vitamin A state.

Br Med J (Clin Res Ed) 1984; 289 doi: (Published 01 December 1984) Cite this as: Br Med J (Clin Res Ed) 1984;289:1484
  1. A N Shepherd,
  2. G J Bedford,
  3. A Hill,
  4. I A Bouchier


    Twenty five patients with primary biliary cirrhosis were studied for vitamin A state. In nine patients found to have low circulating vitamin A concentrations no abnormality was found on electro-oculography or in dark adaptation. A positive correlation was found between retinol binding protein and vitamin A values (r = +0.88; p less than 0.001) and between serum albumin and vitamin A values (r = +0.75; p less than 0.001). A weaker and negative correlation was found between serum bilirubin (r = -0.47; p less than 0.05) and vitamin A values. Patients with primary biliary cirrhosis should not receive regular parenteral or even oral vitamin A supplementation unless dark adaptometry or electrooculography yields an abnormal result.