Intended for healthcare professionals

Research Article

Subcutaneous terbutaline and control of brittle asthma or appreciable morning dipping.

Br Med J (Clin Res Ed) 1984; 288 doi: (Published 09 June 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:1715
  1. J Ayres,
  2. D R Fish,
  3. D C Wheeler,
  4. J Wiggins,
  5. G M Cochrane,
  6. C Skinner


    In a pilot study two patients with brittle asthma and two with morning dipping received terbutaline or a placebo administered subcutaneously either by continuous infusion or in injections every six hours. In two patients brittle asthma was completely suppressed by terbutaline 1 mg/day given by either method. In the two others early morning dipping responded only to continuous subcutaneous infusions of terbutaline 12 mg/day. Terbutaline administered subcutaneously may be an effective treatment in asthmatic patients who show important diurnal variations in air flow.