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Research Article

Paraneoplastic hypercalcaemia in ovarian carcinoma.

Br Med J (Clin Res Ed) 1984; 288 doi: (Published 09 June 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:1714
  1. S G Allan,
  2. S P Lockhart,
  3. R C Leonard,
  4. J F Smyth


    Five patients were seen in whom a raised serum calcium concentration was associated with ovarian carcinoma (clear cell in two cases, cystadenocarcinoma in three). None showed evidence of metastases in bone. The hypercalcaemia occurred as a paraneoplastic phenomenon, but biochemical studies suggested the production of a parathyroid-hormone-like substance. One patient remained free of symptoms of her hypercalcaemia throughout. Paraneoplastic hypercalcaemia due to ovarian carcinoma may be more common than generally recognised and present as a life threatening condition requiring urgent treatment.