Research Article

The sicca syndrome in thalassaemia major.

Br Med J (Clin Res Ed) 1984; 288 doi: (Published 03 March 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:668
  1. C Borgna-Pignatti,
  2. V Cammareri,
  3. P De Stefano,
  4. U Magrini


    A 20 year old man with beta thalassaemia developed symptoms of the sicca syndrome. His serum contained rheumatoid factor and antinuclear antibodies. A biopsy specimen of labial salivary gland showed large accumulations of haemosiderin within the parenchymal cells of the acini. Although in this case the sicca syndrome could not be definitely distinguished from Sjögren's syndrome, the patient's HLA type was not the one usually associated with Sjögren's syndrome. Histological appearances suggested that the causative factor of the sicca syndrome was iron overload owing to an intensive blood transfusion regimen.