Intended for healthcare professionals

Research Article

Adjuvant treatment with polyadenylic-polyuridylic acid in operable breast cancer: updated results of a randomised trial.

Br Med J (Clin Res Ed) 1984; 288 doi: (Published 25 February 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:589
  1. J Lacour,
  2. F Lacour,
  3. A Spira,
  4. M Michelson,
  5. J Y Petit,
  6. G Delage,
  7. D Sarrazin,
  8. G Contesso,
  9. J Viguier


    The results of a randomised trial of polyadenylic-polyuridylic acid given as adjuvant treatment for operable breast cancer were reviewed after a mean follow up period of 87 months. Of the 300 patients included in the original trial, 145 had been allocated to conventional treatment alone and served as controls. At the time of review the overall survival of the group given polyadenylic-polyuridylic acid was significantly improved (p less than 0.05) as compared with that of the controls given conventional treatment alone. Significant benefit (p less than 0.02) was also observed among patients with evidence of disease in lymph nodes, the best results occurring in those with up to three invaded nodes, who showed a significant increase in both overall and relapse free survival. No evidence of toxicity was recorded. These findings confirm the value of polyadenylic-polyuridylic acid as adjuvant treatment for operable breast cancer. Results in an experimental model and in patients receiving the adjuvant suggested a possible role of interferon and natural killer (NK) cells in the mechanism of action.