Research Article

Effects of two antihistamine drugs on actual driving performance.

Br Med J (Clin Res Ed) 1984; 288 doi: (Published 28 January 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:281

This article has a correction. Please see:

  1. T Betts,
  2. D Markman,
  3. S Debenham,
  4. D Mortiboy,
  5. T McKevitt


    A double blind placebo controlled experiment was conducted measuring the effects of the centrally active antihistamine triprolidine and the peripherally acting antihistamine terfenadine on actual driving performance in a group of experienced women drivers. Triprolidine greatly impaired driving behaviour, whereas terfenadine did not. Triprolidine also impaired subjective and objective measures of mood and arousal, and despite an awareness that their driving was impaired while they were taking this agent subjects could not correct their performance. This study suggests that drivers who need antihistamine drugs should avoid those that act centrally.