Intended for healthcare professionals

Research Article

Avascular necrosis of bone caused by combination chemotherapy without corticosteroids.

Br Med J (Clin Res Ed) 1984; 288 doi: (Published 28 January 1984) Cite this as: Br Med J (Clin Res Ed) 1984;288:267
  1. P G Harper,
  2. C Trask,
  3. R L Souhami


    Avascular necrosis of bone is sometimes a complication of cancer chemotherapy that includes corticosteroids but generally occurs at a single site. A patient with testicular teratoma who received chemotherapy that did not include steroids developed avascular necrosis of the left femoral head, left scaphoid, and both medial femoral condyles. Symptoms were relieved with anti-inflammatory drugs and physiotherapy. This case indicates that avascular necrosis may be caused by cancer chemotherapy that does not include steroids.