Intended for healthcare professionals

Research Article

Immunological reason for chronic ill health after infectious mononucleosis.

Br Med J (Clin Res Ed) 1983; 287 doi: (Published 09 July 1983) Cite this as: Br Med J (Clin Res Ed) 1983;287:85
  1. T J Hamblin,
  2. J Hussain,
  3. A N Akbar,
  4. Y C Tang,
  5. J L Smith,
  6. D B Jones


    In a group of patients who suffered from chronic ill health after an attack of acute infectious mononucleosis a disorder of T cell regulation was found. By means of cytochemical reactions the staining pattern associated with T suppressor cells was found in a greater percentage and that associated with T helper cells in a smaller percentage than in normal subjects. In a few patients this finding was confirmed in a functional suppressor assay. The patients were unwell for at least a year but most later made a complete recovery, which was associated with return to normal of the lymphocyte subsets.