Research Article
Immunological reason for chronic ill health after infectious mononucleosis.
Br Med J (Clin Res Ed) 1983; 287 doi: https://doi.org/10.1136/bmj.287.6385.85 (Published 09 July 1983) Cite this as: Br Med J (Clin Res Ed) 1983;287:85- T J Hamblin,
- J Hussain,
- A N Akbar,
- Y C Tang,
- J L Smith,
- D B Jones
Abstract
In a group of patients who suffered from chronic ill health after an attack of acute infectious mononucleosis a disorder of T cell regulation was found. By means of cytochemical reactions the staining pattern associated with T suppressor cells was found in a greater percentage and that associated with T helper cells in a smaller percentage than in normal subjects. In a few patients this finding was confirmed in a functional suppressor assay. The patients were unwell for at least a year but most later made a complete recovery, which was associated with return to normal of the lymphocyte subsets.