Research Article

Diurnal variation of lymphocyte subsets identified by monoclonal antibodies.

Br Med J (Clin Res Ed) 1983; 286 doi: (Published 09 April 1983) Cite this as: Br Med J (Clin Res Ed) 1983;286:1171
  1. J V Bertouch,
  2. P J Roberts-Thomson,
  3. J Bradley


    Monoclonal antibodies specific for lymphocyte subsets were used to examine circulating lymphocytes obtained at frequent intervals from healthy subjects. A diurnal rhythm was found in the total numbers of lymphocytes, T cells, inducer/helper cells, suppressor/cytotoxic cells, Ia positive cells, and B cells. The lowest levels of all subsets were seen at 0900 hours and the highest levels at 2100. In some subjects the ratio of helper to suppressor cells varied considerably during the sample period, though the ratio was relatively constant for the group as a whole.