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Research Article

Erythropoietin and renal function in sickle-cell disease.

Br Med J (Clin Res Ed) 1982; 285 doi: (Published 11 December 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:1686
  1. A G Morgan,
  2. C A Gruber,
  3. G R Serjeant


    The relation between haemoglobin concentration, creatinine clearance, and the serum concentration of erythropoiesis-stimulating factor were assessed in 31 patients with homozygous sickle-cell disease. Haemoglobin concentrations fell significantly with decreasing creatinine clearance (r = 0.58, p less than 0.001) and were positively correlated with the concentration of erythropoiesis-stimulating factor (r = 0.65, p less than 0.001). These observations suggest that erythropoietin concentration is the factor limiting production of red cells in sickle-cell disease with renal insufficiency and have implications for treatment.