Intended for healthcare professionals

Research Article

Decreased plasma motilin concentrations in pregnancy.

Br Med J (Clin Res Ed) 1982; 285 doi: (Published 20 November 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:1453
  1. N D Christofides,
  2. M A Ghatei,
  3. S R Bloom,
  4. C Borberg,
  5. M D Gillmer


    Plasma motilin concentrations were measured in 37 women during the second and third trimester of pregnancy and one week after delivery. The mean plasma motilin concentrations, both fasting and after a glucose load and a mixed meal, were significantly (p less than 0.001) reduced during pregnancy, returning to the normal range one week post partum. Pregnancy appears to have a profound inhibitory effect on plasma motilin, and this may in part be responsible for the gastrointestinal hypomotility associated with pregnancy.