Research Article

Fibronectin in fulminant hepatic failure.

Br Med J (Clin Res Ed) 1982; 285 doi: (Published 30 October 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:1231
  1. J Gonzalez-Calvin,
  2. M F Scully,
  3. Y Sanger,
  4. J Fok,
  5. V V Kakkar,
  6. R D Hughes,
  7. A E Gimson,
  8. R Williams


    Thirteen out of 17 patients with fulminant hepatic failure had plasma fibronectin concentrations below the normal range (194--472 micrograms/ml), the mean concentration in all 17 patients being 117.9 +/- SE 19.4 micrograms/ml. There was a significant negative correlation between plasma fibronectin concentration and aspartate aminotransferase activity, suggesting that fibronectin is consumed during clearance of hepatocyte debris. The reduced availability of fibronectin may be an important factor in the impaired function of Kuppfer cells in patients with fulminant hepatic failure.