Papers And Short Reports

Nuclear magnetic resonance imaging of the brain in children

Br Med J (Clin Res Ed) 1982; 285 doi: (Published 18 September 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:774
  1. M I Levene,
  2. A Whitelaw,
  3. V Dubowitz,
  4. G M Bydder,
  5. R E Steiner,
  6. C P Randell,
  7. I R Young


    A preliminary study of nuclear magnetic resonance imaging of the brains of four normal children (36 weeks' postmenstrual age to 5 years) showed long T1 areas in the periventricular region of the neonate as well as evidence of progressive myelinisation with increasing age. Study of 18 patients of 40 weeks' postmenstrual age to 4 years showed an apparent deficit in myelinisation in an infant with probable rubella embryopathy and another with ventricular dilatation of unknown cause. Abnormal scans were obtained in an infant with congenital muscular dystrophy, and abnormalities were visualised at the lateral ventricular margins in a case of acute hydrocephalus after shunt blockage. Periventricular regions of increased T2 were seen in a term infant aged 4 days after severe birth asphyxia and convulsions.

    Nuclear magnetic resonance imaging appears to provide a unique demonstration of myelinisation in vivo and shows changes in pathological processes of importance in paediatric practice.