Renal and segmental pancreatic grafting with draining of exocrine secretion and initial continuous intravenous cyclosporin A in a patient with insulin-dependent diabetes and renal failure
Br Med J (Clin Res Ed) 1982; 285 doi: https://doi.org/10.1136/bmj.285.6343.677 (Published 11 September 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:677- R Y Calne,
- D J G White,
- K Rolles,
- T J Duffy,
- T Kass
Abstract
A patient with renal failure and insulin-dependent diabetes received renal and segmental pancreatic allografts from the same donor, with exocrine drainage of the pancreas being directed into the bowel. An attempt was made to maintain the serum concentrations of cyclosporin A between 300 and 1000 μg/l to avoid serious nephrotoxicity and rejection. Considerable difficulty was experienced in controlling the serum concentrations even with continuous intravenous infusion. When the concentrations were maintained between 300 and 1000 μg/l function in both allografts was satisfactory.
At seven months the patient required no insulin and had good renal function. He was not receiving corticosteroids.
Log in
Log in using your username and password
Log in through your institution
Subscribe from £173 *
Subscribe and get access to all BMJ articles, and much more.
* For online subscription
Access this article for 1 day for:
£38 / $45 / €42 (excludes VAT)
You can download a PDF version for your personal record.