Research Article

Minimum amount of penicillin prophylaxis required to control Streptococcus pyogenes epidemic in closed community.

Br Med J (Clin Res Ed) 1982; 285 doi: (Published 10 July 1982) Cite this as: Br Med J (Clin Res Ed) 1982;285:95
  1. A Colling,
  2. I Kerr,
  3. W R Maxted,
  4. J P Widdowson


    The prophylaxis required to control an epidemic of Streptococcus pyogenes throat infection in a junior detention centre has been reported. In a further epidemic an attempt was made to determine the minimum amount of penicillin required to control the outbreak. Oral penicillin (0.5 g) given as a single daily dose for 10 days to all boys after entry proved effective. The added risk of relatively deprived adolescent boys developing rheumatic fever is stressed.