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Research Article

Predictive value of SS-B precipitating antibodies in Sjoögren's syndrome.

Br Med J (Clin Res Ed) 1982; 284 doi: (Published 12 June 1982) Cite this as: Br Med J (Clin Res Ed) 1982;284:1738
  1. D A Isenberg,
  2. L Hammond,
  3. C Fisher,
  4. M Griffiths,
  5. J Stewart,
  6. G F Bottazzo


    As part of a screening programme several patients were identified with antibodies to the nuclear antigen SS-B. Fifteen were examined and 11 found to have Sjögren's syndrome, though this had not been suspected by most of the referring physicians. In contrast, among a group of 17 patients with overt Sjögren's syndrome, most of whom also had rheumatoid arthritis, only one had antibodies to SS-B. Patients presenting with polyarthralgia found to be SS-B positive may be likely to develop Sjögren's syndrome but unlikely to develop rheumatoid arthritis. The detection of SS-B antibodies may antedate clinical evidence of Sjögren's syndrome by months or even years. These results emphasise the clinical heterogeneity of Sjögren's syndrome.