For healthcare professionals only

Research Article

Family study of antipyrine clearance.

Br Med J (Clin Res Ed) 1982; 284 doi: (Published 16 January 1982) Cite this as: Br Med J (Clin Res Ed) 1982;284:150
  1. P G Blain,
  2. J C Mucklow,
  3. P Wood,
  4. D F Roberts,
  5. M D Rawlins


    Antipyrine clearance was measured in 208 healthy volunteers from 78 families. After the values had been corrected for weight and sex, antipyrine clearance was observed to be significantly correlated between siblings (r = 0.590) and between spouses (r = 0.320), but not between parents and their offspring. After the clearance values had been corrected for tobacco and oral contraceptive use, there was still no significant correlation between parents and offspring. These results are incompatible with the hypothesis that antipyrine clearance is primarily determined by genetic factors and indicate that environmental influences predominate.