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Research Article

Light-chain nephropathy in patient with renal carcinoma.

Br Med J (Clin Res Ed) 1981; 283 doi: (Published 01 August 1981) Cite this as: Br Med J (Clin Res Ed) 1981;283:339
  1. G Enia,
  2. S Maringhini,
  3. A L'Abbate,
  4. C Zoccali,
  5. Q Maggiore


    Paraneoplastic syndromes are often associated with renal parenchymal tumours. This report describes a case of renal-cell carcinoma with kappa-chain nephropathy. The patient, a 60-year-old man, had renal tubular dysfunction, shown by low serum concentrations of urate and phosphate. Kappa-chains were found in both serum and urine, but no lambda-chains were found. Investigations showed a clear-cell carcinoma, and the patient underwent a radical nephrectomy. Two years after operation serum phosphate and urate concentrations had returned to normal, and kappa-chains were undetectable in serum or urine. The absence of lambda-chains indicates that the light-chain proteinuria was due to overproduction of the M component, and the disappearance of kappa-chains after the operation suggests a causal relation between the renal tumour and the overproduction of the M component.