Coagulation inhibitor in hypothyroidism.Br Med J (Clin Res Ed) 1981; 282 doi: https://doi.org/10.1136/bmj.282.6275.1508 (Published 09 May 1981) Cite this as: Br Med J (Clin Res Ed) 1981;282:1508
- S Ardeman,
- H Boralessa,
- R F Sale
A patient was referred for investigation of heavy bleeding after surgery. He showed several features of hypothyroidism but no goitre. Primary autoimmune hypothyroidism was confirmed by the finding of a low serum thyroxine concentration and a high thyrotropin concentration. Factor VIII concentration was low, and a mild coagulation inhibitor was found. The patient was treated with thyroxine and returned to normal health within a few months. The inhibitor found in this patient may have been specific for factor VIII, but the presence of coagulation inhibitors should be considered in patients with hypothyroidism.