Research Article

Glial origin of rapidly adhering amniotic fluid cells.

Br Med J 1980; 281 doi: (Published 29 November 1980) Cite this as: Br Med J 1980;281:1456
  1. P Aula,
  2. H von Koskull,
  3. K Teramo,
  4. O Karjalainen,
  5. I Virtanen,
  6. V P Lehto,
  7. D Dahl


    Rapidly adhering cells (RA cells) from the amniotic fluid of a pregnancy with fetal anencephaly were investigated by immunofluorescence assay with an antiserum against glial cells. After 24 hours' cultivation a high proportion of the cells showed positive glial-specific fluorescence, whereas no staining was seen in cells from samples of normal amniotic fluid. At the 24th week the mother was delivered of a stillborn infant with anencephaly. Immunofluorescence staining of RA cells with glial-specific antiserum may be used for the differential diagnosis of fetal abnormalities associated with a high alpha-fetoprotein concentration in amniotic fluid.