Research Article

Diuretic treatment of resistant hypertension.

Br Med J 1980; 281 doi: (Published 25 October 1980) Cite this as: Br Med J 1980;281:1101
  1. L E Ramsay,
  2. J H Silas,
  3. S Freestone


    In patients with hypertension resistant to three or four drugs including a thiazide diuretic substitution of frusemide for the thiazide, or the addition of spironolactone, produced significant reductions in blood pressure and body weight. The response did not depend on the presence of overt fluid retention, renal impairment, or the use of antihypertensive drugs of high potency. Women had larger responses than men. Expansion of the plasma or extracellular fluid volume is an important cause of resistance to treatment even when a thiazide diuretic is used. An increase in diuretic treatment should be tried before using the postganglionic adrenergic blockers or minoxidil in resistant hypertension.