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Research Article

Effects of pseudoephedrine and triprolidine, alone and in combination, on symptoms of the common cold.

Br Med J 1980; 281 doi: (Published 19 July 1980) Cite this as: Br Med J 1980;281:189
  1. C E Bye,
  2. J Cooper,
  3. D W Empey,
  4. A S Fowle,
  5. D T Hughes,
  6. E Letley,
  7. J O'Grady


    A total of 466 healthy adults from four different regions of England entered a double-blind, randomised trial to test the effectiveness of an antihistamine (triprolidine) and a decongestant (pseudoephedrine), alone or in combination, in relieving symptoms of the common cold. During the study 199 subjects reported a total of 243 colds. Subjects recorded the severity of 12 symptoms during treatment and noted separately the severity of a further seven symptoms that represented unwanted effects of treatment or served as an index of suggestibility. They were then asked about their overall improvement in symptoms during treatment and whether they thought they had taken placebo. Sneezing, nasal obstruction, and overall response to treatment were significantly improved (p <0.01) with psuedoephedrine or pseudoephedrine and triprolidine compared with placebo.