Research Article

Resetting of osmoreceptor response as cause of hyponatraemia in acute idiopathic polyneuritis.

Br Med J 1979; 2 doi: (Published 08 December 1979) Cite this as: Br Med J 1979;2:1474
  1. M D Penney,
  2. D Murphy,
  3. G Walters


    In a patient with hyponatraemia associated with acute idiopathic polyneuritis plasma concentrations of antidiuretic hormone increased when hypertonic saline was infused intravenously, and urine osmolality rose concomitantly. A water load was excreted normally, while the plasma remained extremely hypo-osmolal. It is concluded that osmoregulation was functioning normally but was set abnormally low, possibly owing to a disturbance of the peripheral volume receptors.