Research Article

O-diphenoloxidase concentrations in leprosy.

Br Med J 1979; 2 doi: (Published 13 October 1979) Cite this as: Br Med J 1979;2:900
  1. K Reza,
  2. S Talib,
  3. S K Imam


    O-diphenoloxidase activity was studied in 15 patients with lepromatous leprosy, 15 with tuberculois leprosy, and 15 controls. O-diphenoloxidase isolated from skin and serum samples of patients with lepromatous leprosy had the specificity of a bacterially derived enzyme and not that of a mammalian-derived enzyme. Only the patients who had lepromatous leprosy for over two years showed enzyme activity in serum, though all showed it in skin tissue. O-diphenoloxidase activity in serum may be a useful diagnostic marker of lepromatous leprosy.