Research Article

Haemodynamic effects of buprenorphine after heart surgery.

Br Med J 1978; 2 doi: (Published 09 December 1978) Cite this as: Br Med J 1978;2:1602
  1. F L Rosenfeldt,
  2. B Houston,
  3. D Thompson,
  4. N Naqui,
  5. A D Malcolm,
  6. B T Williams,
  7. D J Coltart


    The effect of buprenorphine on the cardiovascular system was examined in 11 patients during the period of reduced cardiac reserve after open-heart surgery. Within 10 minutes of giving the full analgesic dose (5 microgram/kg) intravenously the mean heart rate had fallen significantly by six beats/min. Although in two patients the mean arterial pressure fell by 24 mm Hg, there was no overall change in mean arterial pressure, cardiac output, or peripheral resistance. In a further six patients buprenorphine was used successfully as the sole analgesic after open-heart surgery. Buprenorphine appears to be safer than morphine for use in patients with reduced cardiac reserve and is of similar analgesic efficacy.