Research Article

Cimetidine in patients with gastric ulcer: a multicentre controlled trial.

Br Med J 1977; 2 doi: (Published 24 September 1977) Cite this as: Br Med J 1977;2:795
  1. F Frost,
  2. I Rahbek,
  3. S J Rune,
  4. K B Jensen,
  5. E Gudmand-Hoyer,
  6. E Krag,
  7. J Rask-Madsen,
  8. H R Wulff,
  9. J Garbol,
  10. K G Jensen,
  11. M Hojlund,
  12. V R Nissen


    Forty-five adult outpatients with endoscopically confirmed gastric ulceration completed a double-blind trial of either cimetidine (1 g/day) or placebo. After six weeks 18 of the 23 patients receiving cimetidine showed complete ulcer healing compared with only six of the 22 patients receiving placebo. The cimetidine group also had fewer days with pain than the placebo group but the difference was not statistically significant. Cimetidine therefore seems to promote healing of gastric ulcers without severe side effects, although its effect on pain is less pronounced than in patients with duodenal ulcers.