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Research Article

Immune status of children with and without severe infection during remission of malignant disease.

Br Med J 1975; 2 doi: (Published 31 May 1975) Cite this as: Br Med J 1975;2:467
  1. J Graham-Pole,
  2. M L Willoughby,
  3. S Aitken,
  4. A Ferguson


    The immune status of children with malignant disease in remission was assessed usingvarious immune function tests. Children with infections had significantlymore neutropenia, hypogammaglobulinaemia, and impaired cell-mediated immune responses than those without. These two groups combined had much more absolute lymphopenia and impairment of both cell-mediated immunity and antibody-producing capacity thancontrol children with non-malignant conditions. Regular immunological evaluation isrecommended for children with malignant disease when new intensive treatment schedules are under trial and for individual patients particularly prone to develop infections during treatment.