For healthcare professionals only

Papers And Originals

Some Metabolic Effects of Sodium Nitroprusside in Man

Br Med J 1974; 2 doi: (Published 20 April 1974) Cite this as: Br Med J 1974;2:140

This article has a correction. Please see:

  1. C. J. Vesey,
  2. P. V. Cole,
  3. J. C. Linnell,
  4. J. Wilson


    The infusion of sodium nitroprusside during surgical operations produced plasma levels of cyanide of up to four times the control value. Plasma thiocyanate showed little change except during prolonged infusion of the drug, but total plasma B12 tended to fall, as did methylcobalamin. Other cobalamins showed little change after nitroprusside infusion for short periods. During longer infusions the ratio of methylcobalamin to adenosyl + hydroxocobalamin fell and cyanocobalamin concentrations were high.