Effect of Copper-containing Intrauterine Contraceptive Devices on Human Cells in CultureBr Med J 1973; 2 doi: https://doi.org/10.1136/bmj.2.5865.520 (Published 02 June 1973) Cite this as: Br Med J 1973;2:520
- R. W. Jones,
- N. M. Gregson,
- Max Elstein
Intrauterine devices containing copper were introduced into cultures of adult and fetal cells. The Dalkon shield had no apparent effect on cell growth. The Gravigard device caused inhibition of growth and an increase in copper concentration in the supranatant medium. When the latter device was transferred through a series of subcultures the rate of release of copper decreased and growth was no longer inhibited.