Papers And Originals

Interaction between Levodopa and Methyldopa

Br Med J 1973; 2 doi: (Published 14 April 1973) Cite this as: Br Med J 1973;2:90
  1. F. B. Gibberd,
  2. Elizabeth Small


    The interaction between methyldopa and levodopa was studied in 18 patients with Parkinsonism. Together they produced a fall in blood pressure in doses which when given alone had no effect or only a slight hypotensive effect. Severe hypotension never occurred. It is reasonable to give methyldopa to hypertensive patients on levodopa but the regimen should be initiated in hospital.