Papers And Originals

Uncomplicated HL-A Matched Sibling Bone Marrow Graft for Combined Immune Deficiency

Br Med J 1972; 2 doi: (Published 29 April 1972) Cite this as: Br Med J 1972;2:265

This article has a correction. Please see:

  1. M. Yamamura,
  2. R. C. F. Newton,
  3. D. C. O. James,
  4. J. G. Humble,
  5. L. J. Butler,
  6. J. R. Hobbs


    When an apparently identical HL-A donor can be found and satisfactorily checked by the mixed lymphocyte reaction, it is worth attempting simple bone marrow grafting in a patient with combined immune deficiency syndrome who otherwise would die. Immunocompetence was given in this way to a baby girl by her 4-year-old brother and was confirmed by the presence of Y-chromosome in most of the transforming lymphocytes. IgA was late to emerge, presumably owing to the immaturity for IgA of the donor's bone marrow.