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Oral Prostaglandins in the Induction of Labour

Br Med J 1972; 2 doi: (Published 22 April 1972) Cite this as: Br Med J 1972;2:188
  1. Wallace Barr,
  2. W. C. M. K. Naismith


    Prostaglandins E2 and F2α were administered by mouth to induce labour in 24 patients at or past term. The drugs were administered at two-hourly intervals in doses ranging from 0·5 to 1·5 mg for prostaglandin E2 and from 5 to 15 mg for prostaglandin F2α. Of the 10 cases in which prostaglandin E2 was used, labour was successfully induced in eight and there were no side effects. With prostaglandin F2α labour was induced in 12 of 14 patients nine of whom had gastrointestinal disturbance, mostly of mild degree. With both drugs the infant was apparently unaffected and Apgar scores were satisfactory. Uterine hypertonus was not observed and the postpartum blood loss was within normal limits.